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#collagen

14 public questions tagged with this topic.

Which statement is NOT true for collagen? (June 2014)

Triple helix has two α and one β chain, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question. Careful

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Vitamin C deficiency affects collagen by impairing

Hydroxylation of Pro and Lys, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Which collagen type is the most abundant in connective tissue?

Type I, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Which ECM component provides tensile strength?

Collagens, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

The position of the collagen triple helix in the Ramachandran plot is at:

Upper Left correctly identifies the graphical representation, mathematical relationship, or plot parameter described in this question. In Peptide and Ramachandran plo, graphical analysis transforms complex kinetic or biological data into linear relationships that allow precise determination of key parameters. The specific feature described by Upper Left is derived from the mathematical transformation of the underlying equation and has a defined physical meaning. The other options (Upper Right, Bottom Right, and Bottom Left) represent different parameters, intercepts, or slopes from either the same or different analytical methods.

Ref: Campbell Biology, Urry et al., 12th Ed.

Which protein provides structural integrity to skin, tendons, and bones?

Collagen is the scientifically accurate answer to this question. Within the study of Protein, this concept is well-established through extensive research and is documented in standard scientific literature. The specific properties, mechanisms, or characteristics of Collagen directly address what is being asked. Among the other options, Elastin, Keratin, and Fibrillin do not correctly answer this question because they either refer to different concepts, describe properties of other molecules or processes, or represent common misconceptions about this topic.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

The triple-helical structure of collagen is best stabilized by:

Hydrogen bonding between α-chains accurately describes the structural composition or molecular organization asked about in this question. In Protein, knowledge of molecular structure is directly linked to understanding biological function. The specific arrangement of chemical components in Hydrogen bonding between α-chains determines its physical properties, biological activity, and interactions with other molecules. The other options (Covalent bonds between glycine and proline, Van der Waals interactions, and Ionic interactions between side chains) describe different structural arrangements, incorrect stoichiometry, or compositions of different biological molecules.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

Which amino acid is found at every third position in collagen and allows tight helix formation?

Glycine is the scientifically accurate answer to this question. Within the study of Protein, this concept is well-established through extensive research and is documented in standard scientific literature. The specific properties, mechanisms, or characteristics of Glycine directly address what is being asked. Among the other options, Proline, Hydroxyproline, and Lysine do not correctly answer this question because they either refer to different concepts, describe properties of other molecules or processes, or represent common misconceptions about this topic.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

What is the major stabilizing force in collagen triple helix?

Hydrogen bonding between glycine residues accurately defines or describes the concept asked in this question. Within Protein, precise definitions and terminology are essential for clear scientific communication. The other options (Covalent cross-links, Hydrophobic interactions, and Ionic bonding) either describe related but distinct concepts, use incorrect terminology, or confuse similar-sounding terms that have different scientific meanings. A thorough understanding of exact definitions helps distinguish between closely related biological concepts and is crucial for competitive examinations.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

Which enzyme catalyzes the cross-linking of collagen fibrils?

Lysyl oxidase is the accurate response regarding enzymatic activity or regulation described in this question. Enzymes are biological catalysts that accelerate reactions by lowering activation energy through specific substrate binding and transition state stabilization. In the context of Protein, Lysyl oxidase plays a specific catalytic or regulatory role determined by its active site configuration and mechanism of action. The other options (Hydroxylase, Peptidase, and Elastase) are either different enzymes with distinct substrate specificities, act through different mechanisms, or are involved in separate metabolic pathways.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4