Recognition of intracellular pathogens in innate immune cells involves
The principle of cellular compartmentalization and cell cycle explains that SNARE-mediated trafficking, Hayflick limit, P53 and cyclin regulation control proliferation. Hence NOD-like receptors (NLRs) fits best because it aligns with membrane trafficking and cell cycle control, as documented in authoritative sources on cell biology.
Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 10, Membrane Structure and Transport, discusses SNARE proteins, vesicle trafficking, ER, Golgi, endosome membranes and selective transport providing compartmentalization foundation.
