Cell cycle controller is robust and adaptable. Additionally, it functions like a switch to ensure unidirectional cell cy
The principle of cellular compartmentalization and cell cycle explains that SNARE-mediated trafficking, Hayflick limit, P53 and cyclin regulation control proliferation. Hence Positive feedback loops to regulate the activity of cyclin-dependent kinases fits best because it aligns with membrane trafficking and cell cycle control, as documented in authoritative sources on cell
Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 17, Cell Cycle and Regulation, explains Cdc2, cyclins, P53, proteasomes, Hayflick limit, primary culture and immortalization mechanisms governing proliferation.
