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#cell adhesion molecules

5 public questions tagged with this topic.

Fertilization in mammals-l

Izumo protein interacts with egg membrane protein:

Post-acrosome reaction sperm protein Izumo1, Ig-superfamily type I transmembrane protein, becomes relocated to equatorial segment competent for fusion. On egg, cognate binding partner is Juno, GPI-anchored folate receptor 4 enriched on microvillar plasma membrane. High-resolution crystallography shows Izumo1 four-helix bundle interacts with Juno beta-propeller domains providing heterophilic adhesion interface bridging gametes before membrane merger. Association triggers Juno shedding via extracellular vesicles preventing polyspermy. CD9 organizes fusion synapse but core lock-key recognition is Izumo-Juno highly conserved across mammalian species, essential for fertility, monospermy enforcement and egg activation initiation.

Ref: Bianchi et al., Nature 2014: Structural basis of Izumo1-Juno adhesion in gamete recognition and fusion.

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Cell Communication

Which of the following molecules is involved in Ca2+-dependent cell–cell adhesion? (June 2011)

Cadherin, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and Cell Adhesion

IgCAMs are characterized by presence of

Immunoglobulin-like domains, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and Cell Adhesion

Which CAMs are Ca2+-independent?

IgCAMs, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and Cell Adhesion

Leukocyte rolling is mediated by

Selectins, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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