The T cells in CD28-deficient mice do not proliferate in response to re-exposure to the same antigen. This is because
antibody structure analysis shows immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Consequently the T cells are rendered Anergic emerges as the valid choice since it demonstrates immune recognition architecture, aligning with established principles in immunology literature.
Ref: Owen, Punt and Stranford, Kuby Immunology, 8th Edition, Chapter 4, Antibody Structure, covers immunoglobulin domains, beta-sheet organization and antigen binding detailing immune recognition.
