Skip to content
Login Register

#caspases

3 public questions tagged with this topic.

Apoptosis

Executioner caspases mainly function to

Initiator caspases (caspase-8, -9 and -10) are activated by dimerization within large multiprotein platforms such as the DISC or the apoptosome. Once active they cleave and thereby activate the executioner caspases (caspase-3, -6 and -7). Executioner caspases proteolytically dismantle structural proteins, activate nucleases and ultimately produce the morphological hallmarks of apoptosis.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Apoptosis

Initiator caspases are activated primarily by

Initiator caspases (caspase-8, -9 and -10) are activated by dimerization within large multiprotein platforms such as the DISC or the apoptosome. Once active they cleave and thereby activate the executioner caspases (caspase-3, -6 and -7). Executioner caspases proteolytically dismantle structural proteins, activate nucleases and ultimately produce the morphological hallmarks of apoptosis.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Apoptosis

Initiator caspases in mammals include

Initiator caspases (caspase-8, -9 and -10) are activated by dimerization within large multiprotein platforms such as the DISC or the apoptosome. Once active they cleave and thereby activate the executioner caspases (caspase-3, -6 and -7). Executioner caspases proteolytically dismantle structural proteins, activate nucleases and ultimately produce the morphological hallmarks of apoptosis.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details