DNA polymerase III of E. coli is
Mechanistically, nucleic acid structure and recombination involves hairpin formation, Holliday junction resolution and translation control ensure fidelity. This validates required for de novo synthesis of new strands of DNA because it matches molecular mechanisms, a pattern repeatedly demonstrated in molecular biology research.
Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 5, DNA Replication and Repair, discusses Holliday junction formation during homologous recombination and replication fork dynamics ensuring genome duplication.
