Abzymes are antibodies that:
Abzymes catalytic antibodies merge Ig antigen-binding specificity enzyme-like rate acceleration accelerating chemical transformations difficult natural enzymes. Generation exploits transition state analog theory Pauling: enzyme binds transition state tighter substrate lowering activation energy. Immunization stable mimic tetrahedral high-energy intermediate ester hydrolysis phosphonate ester phosphorus replacing carbon maintaining tetrahedral but stable replaces labile carbonyl elicits immune response producing antibodies binding pocket complementary transition state geometry providing binding
Ref: Tramontano Science 1986 Abzyme Catalytic Antibody First Demonstration; Lerner Chem Review Abzymes Concept 1992; Janeway Abzyme Catalytic Activity Binding Energy Chapter 5.