Which ion channel is involved in action potential generation?
Action potential propagation in excitable cells depends on rapid voltage dependent changes in sodium and potassium conductances. Resting potential near minus 70 millivolts maintained by K+ leak and Na+/K+ ATPase. Upon synaptic depolarization reaching threshold about minus 55 millivolts, voltage sensor S4 helices of sodium channels containing repeated Arg-X-X motifs move outward within 100 microseconds, opening activation gate formed by S6 crossing. Sodium electrochemical gradient strong due to 145 millimolar outside, 12 millimolar inside and negative membrane potential drives inward current, d
Ref: Alberts et al., Molecular Biology of the Cell, Chapter 11: Voltage-Gated Na+ Channels in Action Potentials.