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What is the significance of the mass-energy equivalence in nuclear physics?

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**Binding energy calculation** from mass defect, for nucleus mass number 28 BE 224 MeV BE/A=8 MeV, A=18 BE 144 MeV BE/A=8 MeV, BE/A indicates stability, fusion of light nuclei and fission of heavy release energy because product has higher BE/A, difference released. Einstein’s E = m c² explains how mass defect converts into binding energy, unifying mass and energy conservation and enabling the understanding of energy release in nuclear reactions. Using E_n = -13.6/n² eV, r_n = n² a₀, L = n h/2π, R = R₀ A^¹/³, BE = Δm c² and 1 u = 931.5 MeV, evaluation yields Explains binding energy, consistent with Bohr

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