Practice question

Question

In mice, the gene encoding TbxS Is transcribed In limb fields of the forelimbs, while the genes encoding Isletl, Tbx4 and Pitxl are expressed in presumptive hindlimbs. Following statements are made about limb development in mouse: A. Loss of Tbx5 gene results in complete failure of forelimb formation. B. Hindlimb bud growth and initial patterning appears normal when Tbx4 is knocked out, although leg development is arrested prematurely. c. Misexpression of Pitx1. in forelimb ceases development of muscles, bones and tendons. D. When Islet1 Is Inactivated specifically In the lateral plate mesoderm, the hlndllmbs still develop. Which one of the following options represents a combination of correct statements?