Practice question

Question

In eukaryotes, DNA replication must occur with extreme accuracy and only once to prevent the damaging effects of gene amplification. The following statements were made regarding possible mechanisms Involved In achieving tight regulation of DNA replication: A. High APC/C activity In mitosis and early G1 phase of the cell cycle that triggers the destruction of Cdt1 Inhibitor geminin, thus allowing Cdt1 to be active In early G1 to load helicases. B. Activation of S-Cdks that regulate the phosphorylation of specific Initiator proteins In the 5-phase. c. MCM helicase loads at the s-phase of the cell cycle, so that replication begins only at s-phase. D. Cdc6 and Cdt1 bind to the origin recognition complex (ORC) and help In pre-replicative complex assembly only after mitosis. Which one of the options has all correct statements?