Practice question
Question
In eukaryotic cells, replication initiation from a replication origin occurs only once per cell cycle and S- phase CDKs play a vital role in the regulation of DNA replication . In budding yeast a protein complex known as the origin recognition complex (ORC) is associated with DNA replication origin during G1; however origins fire only once at the beginning of S-phase. DNA replication does not start in G1 because: A. MCM helicases are inactive in G1. B. Spindle checkpoint is active in G1. C. DNA polymerase is not recruited in G1. D. ORC and initiation factors Cdc6 and Cdt1 do not recruits MCM helicases to the site of replication initiation in G1. Which of the above statements are correct.
Explanation
Analysis of in eukaryotic cells, replication initiation from a shows A and C represents established outcome. functional assays supports option B, whereas distractors confuse substrate or regulatory direction and fail to reproduce observed results.
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