Practice question
Question
Given below are two statements regarding T-cell receptor (TCR) affinity and selection : Statement I : Fewer than 5% of thymocytes produce TCRs that bind to MHC-peptide complexes with high affinity. These will survive and mature. Statement II : More than 90% of thymocytes produce TCRs that either do not bind to MHC/peptide complexes or bind them with very low affinity. These die by neglect. Choose the most appropriate answer:
Explanation
In thymus, 90-95% thymocytes fail positive selection due to no/low MHC binding and die by neglect. Only ~5% with low-intermediate affinity receive survival signals. High-affinity self-reactive clones undergo negative selection-mediated apoptosis, contrary to statement I, making II correct alone.
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