Practice question
Question
Given below are protein domains and their binding specificities. Column X Column Y Interaction domain Binding site A. SH2 domain i. Phosphorylated tyrosine residue on receptors B. SH3 domain ii. Charged head groups of specific phosphoinositides on plasma membrane C. PH domain iii. Short proline-rich amino acid sequence on proteins D. PTB domain Which one of the following options represents all correct matches between Column X and Column Y?
Explanation
given below are protein domains and their operates via A-i , B-iii , C-ii , D-i represents established outcome. functional assays validates option D. Other options propose substrate or regulatory direction, inconsistent with published kinetics and mutant phenotypes.
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