Practice question
Question
A cytoplasmic monomeric protein containing a single non-surface exposed cysteine residue precipitates upon mutation of the Cys to 'lle'. However, the mutation of Cys to 'Ala' leads to a soluble and functional protein equivalent to the native form. Which one of the following statements explains the above observations?
Explanation
a cytoplasmic monomeric protein containing a single operates via Cys mutated to 'lle' causes steric hindrance in the core of represents established outcome. functional assays validates option D. Other options propose substrate or regulatory direction, inconsistent with published kinetics and mutant phenotypes.
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