Practice question
Question
Which of the following is a protein modification that can initiate the degradation of the modified protein?
Explanation
Polyubiquitination via E1-E2-E3 cascade tags proteins with Lys48-linked ubiquitin chains, targeting them to 26S proteasome for degradation. This regulates cell cycle and quality control, unlike lipid modifications which affect localization rather than proteolysis.
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