Practice question

Nucleosome core contains four canonical histones H2A, H2B, H3, H4 forming octamer wrapping 147 base pairs. H1 differs structurally and functionally as fifth histone. Called linker histone, it does not integrate inside octamer but binds at dyad where DNA enters and exits nucleosome, protecting additional twenty base pairs to generate chromatosome of 167 base pairs. Its central winged-helix globular domain plus long lysine-rich C-terminal tail neutralizes linker DNA, facilitates folding of beads-on-string 11 nanometer fiber into 30 nanometer fiber and stabilizes higher-order condensation during interphase and mitosis.