Practice question

Mitochondrial outer-membrane permeabilization (MOMP) releases cytochrome c into the cytosol. Cytochrome c binds Apaf-1, inducing formation of the heptameric apoptosome that recruits and activates caspase-9. Active caspase-9 then propagates the cascade by cleaving executioner caspases. MOMP is therefore the point of no return for the intrinsic apoptotic pathway. Careful