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Practice question

MCQ

Question

LDL binds with cell surface receptor and gets internalized via clathrinmediated endocytosis. This process helps in maintaining the cholesterol-LDL level in the plasma. However, in a disease known as familial hypercholesterolemia (FH), very high levels of plasma cholesterol is found. This could be due to mutation in which one of the following genes in FH patients?

Options

Choose one · Correct answer highlighted

Explanation

The principle of metabolic engineering and inheritance explains that exogenous gene introduction and pathway extension enable trait improvement. Hence LDL receptor fits best because it demonstrates metabolic extension and combinatorial biosynthesis, as documented in authoritative sources on genetics and biotechnology.

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