Practice question

Question

During physical exercise, a large amount of oxygen is delivered to the active muscles by many physiological adjustments including a change in the P₅₀value (which is determined by Po₂ at which hemoglobin is half-saturated with oxygen). The following proposed statements explain the mechanism of change in P₅₀during exercise: A. P₅₀is increased during exercise as the temperature rises in active muscles. B. During exercise, metabolites accumulate in the active muscles resulting in higher pH that increases P₅₀. C. P₅₀is increased during exercise as CO₂is decreased in active muscles. D. An increase in 2,3-DPG has been reported in non-trained person within 60 min of exercise resulting in higher P₅₀. Which one of the following options represents the correct combination of the above statements?