Practice question

Centromeres provide mechanical linkage essential for chromosome segregation. At centromeric DNA, histone H3 variant CENP-A replaces canonical H3 assembling specialized nucleosomes that directly recruit constitutive centromere associated network CCAN proteins including CENP-C and CENP-T. This platform builds kinetochore, large multiprotein structure containing KMN network that captures spindle microtubule plus ends during mitosis and meiosis. It ensures biorientation, tension sensing via Aurora B kinase and equal segregation. Without functional centromere kinetochore cannot assemble leading to aneuploidy, unlike roles in replication or telomere maintenance pathways.