Practice question

Acrosome is large secretory vesicle capping anterior half of sperm nucleus, formed during spermiogenesis from Golgi apparatus of developing spermatid. Golgi cisternae generate proacrosomic vesicles containing hydrolytic enzymes that coalesce into single acroblast near nucleus then flatten over it, under manoeuvre of acroplaxome. Contents include acid hydrolases typical of lysosome-like organelle but origin is Golgi, not mitochondria, lysosomes or endoplasmic reticulum. Enzyme sorting involves mannose-6-phosphate-like pathways; disruption of Golgi trafficking proteins such as Pick1 results in globozoospermia lacking acrosome, confirming Golgi ancestry essential for male fertility.