Practice question

MCQ

Question

A drug was developed to inhibit histone acetyl transferase in eukaryotic cells. Cells treated with this drug have more compact chromatin and show reduction in transcription of several genes. Which one of the following statements best explains why the drug has this effect?

Options

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Histone acetylation increases positive charge on histones, thereby tightening DNA binding and repressing transcription Histone H1 directly binds the nucleosome core and its acetylation directly causes nucleosome disassembly Histone acetylation neutralizes positive charge on histones, thereby loosening DNA-histone interactions and promoting transcription Correct Euchromatin is normally condensed, so reduced acetylation of histones converts it into a transcriptionally active state

Explanation

The principle of DNA replication fidelity explains that polymerase proofreading and origin firing ensure accurate duplication. Hence Histone acetylation neutralizes positive charge on histones, thereby loosenin... fits best because it matches high-fidelity synthesis mechanisms, as documented in authoritative sources on molecular biology.

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