Practice question
Question
Lethally irradiated mice were split into 4 groups and experiments were conducted as described below: Group 1 was not given any cells. Group 2 was given thymus-derived cells from a syngeneic donor, and two months later. immunized with a polysaccharide antigen. Group 3 was given bone marrow cells from a syngeneic donor, and two months later, immunized with a polysaccharide antigen. Group 4 was given bone marrow cells from a syngeneic donor, and two months later, immunized with a T-dependent antigen. Four possible outcomes, listed below, were suggested. A. Group 1 mice are unlikely to survive. B. Group 2 mice are likely to produce antibodies in response to polysaccharide antigens. C. Group 3 mice are likely to produce antibodies in response to polysaccharide antigens. D. Group 4 mice are likely to produce antabodies in response to T-dependent antigens. Which one of the following options represents the combination of all correct statements?
Explanation
Analysis of lethally irradiated mice were split into 4 shows A, C and D represents established outcome. functional assays supports option D, whereas distractors confuse substrate or regulatory direction and fail to reproduce observed results.
Discussion
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