Practice question

Question

The mammalian protein HP1 plays a major role in heterochromati-nization and silencing. The following mutations are proposed to negatively impact HP1 function. A. Mutation inactivating the deacetylase that targets H3K14Ac B. Mutation inactivating HP1 bromo-domain C. Mutation inactivating HP1 chromo-domain D. Mutation inactivating the KMTlA methyltransferase whose target site is H3K9 Which one of the following combinations represents all correct statements?