Practice question
Question
In persons suffering from sickle cell anemia, the 6th amino acid of beta globin protein is valine instead of glutamic acid. This has occurred due to substitution mutation leading to a change in glutamic acid codon to valine codon in the gene. The mutation is a
Explanation
In biochemistry, enzyme catalysis and lipid structure dictates that substrate affinity, transition state stabilization and phospholipid composition govern function. Therefore transition where purine base changes to a pyrimidine base is correct as it reflects catalytic efficiency and membrane organization, supported by mechanistic studies and conserved across related systems.
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