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#receptor binding

2 public questions tagged with this topic.

Paracrine Factor

Which pathway is primarily activated by the binding of FGFs to their receptors?

FGFR activation recruits adaptor FRS2α leading to Grb2-SOS complex activating Ras-MAPK cascade, PI3K-AKT survival, plus direct PLCγ calcium release and STAT activation via scaffolds and direct phosphorylation. JAK-STAT pathway becomes engaged via STAT1,3,5 phosphorylation by FGFR kinase activity or associated Jak1/2 kinases, regulating chondrocyte growth arrest and immune genes SOCS3, p21. Although MAPK is primary developmental route for proliferation and patterning, JAK-STAT mediates FGFR3 dwarfism through STAT1 nuclear accumulation inhibiting cell cycle progression via Cip/Kip inhibitors. Wnt/beta-catenin is separate pathway activated by Frizzled, not typical FGF downstream, highlighting overlapping downstream networks sharing effectors.

Ref: Powers et al., Endocrine Reviews: FGFR activation engages JAK-STAT downstream of FRS2 adaptor in chondrocytes.

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Cell Signaling Fundamental Principles

Multiple binding sites are indicated by

curved plot, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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