Which of the following interactions contributes least to the stability of a DNA double helix?
London dispersion forces accurately identifies the binding site, binding partner, or molecular interaction described in this question. In Chemical Bonding, molecular recognition and binding specificity are governed by complementary shape, charge, and hydrophobic interactions between molecules. London dispersion forces binds at the specified location due to its structural complementarity and specific non-covalent or covalent interactions. The other options (Base stacking interactions, Hydrogen bonding between base pairs, and Covalent bonds in sugar-phosphate backbone) describe binding to different sites, involve different types of molecular interactions, or represent incorrect binding partners.
Ref: Campbell Biology, Urry et al., 12th Ed.