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Question

Which one of the following eIF2α kinases get activated during unfolded protein response (UPR) in mammalian cells?

Options

Choose one · Correct answer highlighted

Explanation

The principle of enzyme catalysis and lipid structure explains that substrate affinity, transition state stabilization and phospholipid composition govern function. Hence PERK fits best because it reflects catalytic efficiency and membrane organization, as documented in authoritative sources on biochemistry.

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