Practice question
Question
A single nucleotide substitution (C has been replaced by A) has taken place in a gene, but the protein sequence is not altered. What is the type of such variant called as?
Explanation
Genetic code is degenerate, with multiple codons encoding same amino acid. A C to A change causing same residue preserves protein sequence, termed synonymous or silent variant. It may still influence splicing or translation kinetics despite unchanged primary structure.
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