Practice question
Question
A G protein-coupled receptor (GPCR) is a cell-surface transmembrane receptor that works with the help of a G-protein. Choose the correct option for the role of G-protein :
Explanation
GPCR activation promotes guanine nucleotide exchange on heterotrimeric G-alpha subunit, replacing GDP with GTP. GTP-bound alpha dissociates to regulate effectors like adenylyl cyclase. Intrinsic GTPase later hydrolyzes GTP to GDP terminating signaling cascade.
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