Practice question
Question
Type I hypersensitivity is mediated by which of the following immunoglobulins?
Explanation
Type I immediate hypersensitivity involves IgE binding to Fc epsilon RI on mast cells and basophils. Cross-linking by allergen triggers degranulation, releasing histamine, leukotrienes and cytokines causing allergy, asthma and anaphylaxis. IgE levels rise during allergic sensitization.
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