Practice question
Question
The mechanism by which B cells ensure that only one heavy and one light chain allele is translated is referred to as
Explanation
Allelic exclusion ensures each B cell expresses only one parental heavy-chain and one light-chain allele after successful VDJ recombination, preventing dual specificity. This is mediated by feedback inhibition of recombination activating genes, distinct from co-dominance or isotypic selection mechanisms.
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