Practice question
Question
The effect of mutations in a gene at their transcriptional and translational levels were analyzed using Northern (N) and Western (W) blot techniques, respectively. The following figure shows the schematic representation of mRNA and protein expression profiles of the wild-type and its four different mutants. Which one of the following mutants contains mutation in the upstream regulatory region of the gene?
Explanation
Biologically, DNA replication fidelity operates via polymerase proofreading and origin firing ensure accurate duplication. Thus Mutant-4 is appropriate since it matches high-fidelity synthesis mechanisms, reinforcing core concepts taught in molecular biology.
Discussion
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