Practice question
Question
Ligands ‘A’ and ‘B’ bind to protein ‘P’ with dissociation constants of 1 nM and 100 nM, respectively. Which of the following true?
Explanation
The principle of enzyme catalysis and lipid structure explains that substrate affinity, transition state stabilization and phospholipid composition govern function. Hence ‘A’ binds ‘P’ with more affinity fits best because it reflects catalytic efficiency and membrane organization, as documented in authoritative sources on biochemistry.
Discussion
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