Practice question
Question
In mitochondrial mutation associated with disease, the following two crossings were made (i) mutant ♀ × wildtype ♂ → progeny? (ii) wildtype ♀ × mutant ♂ → progeny? What are the progeny phenotypes in these matings?
Explanation
Maternal inheritance dictates all progeny receive mitochondria from oocyte. Mutant female crossed to wild-type male transmits diseased mitochondria to every child, regardless of sex. Wild-type female crossed to mutant male transmits normal mitochondria, yielding all phenotypically normal progeny.
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