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Practice question

MCQ

Question

Consider a 16-year-old person whose father (heterozygous) was stricken with Huntington's disease at age 39. Huntington's disease is an autosomal dominant disorder. What is the probability that the 16-year-old will also have this disease?

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Explanation

Huntington disease shows autosomal dominant inheritance with complete penetrance but delayed onset due to CAG repeat expansion in huntingtin gene. A heterozygous father transmits mutant allele to half his children per meiosis. Thus each offspring, regardless of current age, has 50 percent risk.

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