Practice question
Question
A reference set of molecules is experimentally assayed for xenobiotic toxicity using the MTS assay which is a colorimetric measurement of cell viability. As part of the lead optimization step in drug discovery, which one of the following steps can be used to predict the toxicity of a new set of compounds?
Explanation
In aptitude and reasoning, quantitative reasoning dictates that ratio, percentage and series logic determine correct calculation. Therefore Building a regression model of the reference compounds using molecular descri... is correct as it meets mathematical and logical criteria, supported by mechanistic studies and conserved across related systems.
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