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#HSCs

2 public questions tagged with this topic.

Stem Cell -l

Hematopoietic stem cells (HSCs) can differentiate into:

Hematopoietic stem cells reside in bone marrow endosteal and perivascular niches, characterized by CD34, Sca-1, c-Kit markers in mouse. They are multipotent, giving rise to all blood lineages through stepwise commitment: common myeloid progenitor producing erythrocytes, platelets, granulocytes, monocytes, and common lymphoid progenitor producing B, T, and NK cells. Regulation involves transcription factors GATA1, PU.1, Ikaros, cytokines SCF, IL-3, IL-7. HSCs do not generate neurons, epithelial cells, or muscle fibers under normal physiology, maintaining strict hematopoietic fate through niche-derived Notch and Wnt signals.

Ref: Orkin & Zon, Cell 2008; Gilbert, 12th ed., Chapter 6: Hematopoietic stem cells.

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Stem Cell -lll

Hematopoietic stem cells (HSCs) are classified as:

Hematopoietic stem cells isolated from bone marrow as lineage negative Sca1 positive cKit positive population sustain all blood lineages including myeloid granulocytes, monocytes, erythroid cells and lymphoid B and T cells but not extraembryonic or non-hematopoietic tissues, defining multipotency within hematopoietic system. They self-renew long-term repopulating irradiated recipients and serial transplantation, generate committed progenitors common myeloid progenitor and common lymphoid progenitor via transcription factors GATA1, PU.1, Ikaros. Totipotent generates entire organism including placenta, pluripotent all embryonic lineages, unipotent single lineage like spermatogonial stem. Multipotent classification reflects restricted potential to multiple lineages within one germ layer derived system maintaining lifelong hematopoiesis.

Ref: Orkin and Zon, Hematopoiesis, Chapter 2: Multipotent Hematopoietic Stem Cells Classification.

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