Practice question
Question
TRIF-dependent signaling is characteristic of
Explanation
Most Toll-like receptors signal through the adaptor MyD88, which recruits IRAK kinases and ultimately activates NF-κB and MAP kinases. TLR3 and the endosomal form of TLR4 instead use the adaptor TRIF to activate IRF3 and type-I interferon production. The choice of adaptor therefore determines the balance between inflammatory and antiviral transcriptional programs.
Related blogs
Guides and insights connected to this topic
RT-PCR: Definition, Principle, Enzymes, Types, Steps, Uses
Polymerase chain reaction (PCR) is a temperature-dependent nucleic acid amplification technique used to amplify the DNA or&nb...
Bacteriophage- Definition, Structure, Life Cycles, Applications, Phage Therapy
Bacteriophage Bacteriophage or Phage is a virus that infects and replicates only within the body of bacteria. Bacteriophages were discovered...
Ultracentrifuge- Definition, Principle, Types, Parts, Procedure, Uses
Ultracentrifuge Ultracentrifuge is a sophisticated and advanced centrifuge that operates at an extremely high speed and separates smaller mo...
Discussion
Comments
Please log in to join the discussion.
Login to commentNo comments yet. Be the first to start the discussion.