Practice question

Roux-Weismann experiment involved Wilhelm Roux ablating one blastomere of a two-cell frog embryo with a hot needle, observing development of half embryos lacking structures normally contributed by destroyed cell. Influenced by Weismann's germ plasm theory proposing progressive division of determinants, he interpreted result as supporting mosaicism where fate is progressively restricted during cleavage. Although later refined experiments using clean separation with hair loop showed regulation, initial conclusion framed amphibian development as autonomous. This historic experiment catalyzed exploration of fate maps and eventual discovery of organizer, highlighting interplay between autonomous and regulative models.