SH3 domains recognize
Src-homology 3 (SH3) domains bind short proline-rich motifs conforming to the consensus PxxP. These interactions mediate assembly of signaling complexes independently of phosphorylation and are common in pathways that regulate cytoskeletal dynamics, endocytosis and kinase localization. The modular nature of SH3 domains allows combinatorial assembly of diverse multiprotein complexes. Careful
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)