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#fractional saturation

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Cell Signaling Fundamental Principles

Equation for fractional saturation is

Fractional saturation Y is defined as the concentration of ligand-bound receptor divided by the total receptor concentration, Y = [RL]/([R] + [RL]). Under equilibrium mass-action kinetics this expression simplifies to Y = [L]/(Kd + [L]). The equation predicts a hyperbolic binding isotherm whose midpoint occurs when free ligand concentration equals Kd, providing a direct experimental route to affinity determination.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling Fundamental Principles

Fractional saturation (Y) is defined as

Fractional saturation Y is defined as the concentration of ligand-bound receptor divided by the total receptor concentration, Y = [RL]/([R] + [RL]). Under equilibrium mass-action kinetics this expression simplifies to Y = [L]/(Kd + [L]). The equation predicts a hyperbolic binding isotherm whose midpoint occurs when free ligand concentration equals Kd, providing a direct experimental route to affinity determination.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details