Practice question
Question
Phosphodiesterase terminates GPCR signaling by converting
Explanation
Cyclic-nucleotide phosphodiesterases hydrolyze cAMP or cGMP to the corresponding inactive 5'-monophosphates, thereby terminating the second-messenger signal. Regulation of phosphodiesterase activity provides an important mechanism for controlling the duration and amplitude of cyclic-nucleotide signaling in cells. These enzymes are important pharmacological targets for modulating cyclic nucleotide levels. Careful
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