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#DAG

3 public questions tagged with this topic.

Cell Signaling GPCR Pathways - I

DAG mainly activates

Diacylglycerol remains in the plasma membrane after phospholipase C cleavage of PIP2 and recruits conventional and novel isoforms of protein kinase C. Membrane-bound PKC then phosphorylates a wide range of substrates that regulate cell growth, differentiation and metabolism. The simultaneous production of DAG and IP3 therefore coordinates membrane-localized and calcium-dependent branches of the signaling pathway.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

PLCβ hydrolyzes PIP2 to generate

IP3 and DAG, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cell Signaling GPCR Pathways - I

DAG activates

Diacylglycerol remains in the plasma membrane after phospholipase C cleavage of PIP2 and recruits conventional and novel isoforms of protein kinase C. Membrane-bound PKC then phosphorylates a wide range of substrates that regulate cell growth, differentiation and metabolism. The simultaneous production of DAG and IP3 therefore coordinates membrane-localized and calcium-dependent branches of the signaling pathway.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details