Practice question

Diacylglycerol remains in the plasma membrane after phospholipase C cleavage of PIP2 and recruits conventional and novel isoforms of protein kinase C. Membrane-bound PKC then phosphorylates a wide range of substrates that regulate cell growth, differentiation and metabolism. The simultaneous production of DAG and IP3 therefore coordinates membrane-localized and calcium-dependent branches of the signaling pathway.