Which factor is responsible for the formation of new species through random changes in gene frequency?
Genetic drift, especially in small populations, causes random changes in gene frequency that can lead to speciation. This follows from NCERT principle where relation explains outcome clearly for students.
Ref: NCERT Biology Textbook for Class XI and XII (Zoology section), Chapter: Biology - Zoology portion covering relevant system and function, Topic: Structural organization and physiology.