Which of the following is an example of therapeutic monoclonal antibody?
Rituximab illustrates first FDA approved chimeric therapeutic monoclonal antibody transforming oncology and autoimmunity management. Engineering used recombinant DNA swapping murine variable regions conferring CD20 specificity onto human IgG1 kappa constant domains, approximately 65 percent human to reduce HAMA human anti-mouse antibody response while retaining effector function. Constant region Fc glycosylated at Asn297 in CH2 domain with fucosylated biantennary glycan necessary for high affinity interaction with FcγRIIIa on natural killer cells and macrophages. Production in Chinese hamster
Ref: FDA Monoclonal antibody Rituximab label; Nature Rev Drug Discov 2018 17:31 chimeric anti-CD20 B depletion lymphoma.