The SCF complex plays a crucial role in:
SCF complex, acronym for SKP1-CUL1-F-box protein, represents prototypical cullin-RING ubiquitin ligase family controlling G1/S transition through regulated proteolysis of CDK inhibitors. Core scaffold comprises elongated Cullin1 linking adaptor SKP1 and RING domain protein Rbx1 that recruits E2 ubiquitin-conjugating enzyme. Substrate specificity arises from interchangeable F-box proteins containing leucine-rich repeats or WD40 domains that bind phosphorylated degrons. In budding yeast, F-box Cdc4 recognizes Sic1 inhibitor after phosphorylation by Cln-CDK1 at multiple CDK consensus sites, while
Ref: Morgan, The Cell Cycle: Principles of Control, 2nd ed., Chapter 5: SCF Ligases and CDK Inhibitors.